The Implications of Intergenic Polymorphism for Major Histocompatibility Complex Evolution
نویسندگان
چکیده
منابع مشابه
The implications of intergenic polymorphism for major histocompatibility complex evolution.
A systematic survey of six intergenic regions flanking the human HLA-B locus in eight haplotypes reveals the regions to be up to 20 times more polymorphic than the reported average degree of human neutral polymorphism. Furthermore, the extent of polymorphism is directly related to the proximity to the HLA-B locus. Apparently linkage to HLA-B locus alleles, which are under balancing selection, m...
متن کاملMajor Histocompatibility Complex: Polymorphism from Coevolution
There are many examples of pathogens adapting toward evasion of immune responses. Viruses, such as influenza, rapidly alter their genetic make-up, and each year there appear to be sufficient susceptible hosts that lack memory lymphocytes from previous influenza infections to give rise to a new epidemic (Both et al. 1983; Smith et al. 1999). During human immunodeficiency virus (HIV) infection, s...
متن کاملMajor Histocompatibility Complex Polymorphism in Reptile Conservation
—Genes of the major histocompatibility complex (MHC) are closely related to disease resistance and immune response in vertebrates. Although many groups are well represented in the MHC literature, less attention has been given to reptiles. Here we summarize reptile MHC studies, review published accounts investigating links between MHC polymorphism, parasite resistance, and mate choice, evaluate ...
متن کاملThe major histocompatibility complex.
The major histocompatibility complex on the sixth chromosome controls expression of a complex series of cell surface antigens which comprise the human leukocyte antigen (HLA) system. These markers, beyond their importance in human organ transplantation, have been demonstrated to occur with an increased prevalence in certain disease states. The group of conditions showing the closest association...
متن کاملThe Evolution of Mating Preferences and Major Histocompatibility Complex Genes.
House mice prefer mates genetically dissimilar at the major histocompatibility complex (MHC). The highly polymorphic MHC genes control immunological self/nonself recognition; therefore, this mating preference may function to provide "good genes" for an individual's offspring. However, the evidence for MHC-dependent mating preferences is controversial, and its function remains unclear. Here we p...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Genetics
سال: 2000
ISSN: 1943-2631
DOI: 10.1093/genetics/156.2.867